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Low glutathione levels can manifest through symptoms like fatigue, frequent infections, slow recovery from illness, or signs of oxidative stress such as skin issues or inflammation

Glutamate receptors, AMPA, kainate and NMDA have also being recognized as crucial players at later stages of neurogenesis and have been clearly identified as critical elements of neuronal plasticity in newly born neurons in the adult brain AMPA, kainate, and NMDA are the three main receptors for glutamate

This mechanism underscores the intricate relationship between oxidative stress, inflammation, and BBB integrity, all of which are critical factors in the development and progression of neurodegenerative diseases like Alzheimers disease (AD)

Moreover, the impact of GPER on the cellular energy status extends beyond mitochondrial oxidative phosphorylation, as it modulates various signaling pathways [220]

Data Availability: All relevant data are within the manuscript and Supporting Information files