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Methotrexate [ep Monograph] 189

Besides the previously observed involvement of phenolic compounds, ascorbate peroxidase and proline in the light spectrum-controlled adaptation to drought, probably other antioxidants and amino acids, participate in this process

In addition, multiple other SNP have been found in the SLC22A4 gene, with functional characterisation of eight non-synonymous SNP in Chinese and Indian populations of Singapore finding four of the variants had reduced transporter activity (Reference Toh, Cheung and Murray60)