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Figures 1B , 3 ), resulting in down-regulation of the hepatic GHR expression, as inferred from reductions in circulating levels of GHBP (59), and decreased GH binding (60)

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To the best of our knowledge, animal models have been mostly built by exposure to CS, intranasal instillation of elastase and intraperitoneal injection of CSE (Barreiro et al., 2019)

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Cell-based assays have been used to study GHK-Cu's relationship with VEGF and related angiogenic factors, exploring the compound's role in vascular biology research models