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HTC-based conversion of BRD4 ligands into degraders To evaluate the extensibility of this approach, we sought to convert JQ1, a potent and selective BET (BRD2, BRD3 and BRD4) bromodomain ligand 59 , into molecular glue degraders, several of which have been reported recently 23,24,25,34,60,61

59 mtDNA-encoded proteins are mainly involved in the respiratory chain and are therefore key components of cellular energy production

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Hayashi, M., Yamamoto, Y., Ibusuki, M., Fujiwara, S., Yamamoto, S., Tomita, S., et al

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