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Positive results from the Phase II WILLOW study and Phase III ASPEN study demonstrate that compared to placebo controls, DPP1 inhibition treatment can significantly extend time intervals to first acute exacerbations in bronchiectasis patients and effectively reduce overall acute exacerbation occurrence frequency (Zhong et al., 2025

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Once-daily evening or bedtime dosing is the most common structure, chosen to track the body's natural nighttime GH release