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Mutations in FXN lead to impaired ironsulfur cluster formation, triggering intracellular iron starvation responses that paradoxically result in mitochondrial iron overload, oxidative stress, and subsequent cellular dysfunction (386)

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Every batch is tested by a US-based analytical laboratory before release, including identity by mass spectrometry (LC-MS), purity by HPLC, and bacterial endotoxin screening (LAL)