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Similar content being viewed by others Introduction By 2026, research has indicated that major depressive disorder (MDD) is associated with abnormalities in neuroimmune, metabolic, and oxidative stress (NIMETOX), which seem to influence its pathophysiology and causation [1]

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Serine metabolism is recently shown to regulate inflammatory macrophage functions, which can be attributed to the activation of inflammatory signals through one carbon metabolism or nicotinamide adenine dinucleotide (oxidized form) ( 16 , 19 )

Ridker PM, Rifai N, MacFadyen J, Glynn RJ, Jiao L, Steg PG, Miller M, Brinton EA, Jacobson TA, Tardif JC, Ballantyne CM, Mason RP, Bhatt DL (2022) Effects of randomized treatment with icosapent ethyl and a mineral oil comparator on interleukin-1, interleukin-6, c-reactive protein, oxidized low-density lipoprotein cholesterol, homocysteine, lipoprotein(a), and lipoprotein-associated phospholipase a2: a reduce-it biomarker substudy