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The succinate-ubiquinone oxidoreductase subunit A (SDHA) is part of complex II of the respiratory chain and catalyzes the reaction of succinate to fumarate in the tricarboxylic acid cycle

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Preclinical studies in animal models have yielded several noteworthy findings

Proc Natl Acad Sci USA 114:31863191 Gonfloni S, Di Tella L, Caldarola S, Cannata SM, Klinger FG, Di Bartolomeo C, Mattei M, Candi E, De Felici M, Melino G et al (2009) Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death

Materials and methods Drugs and chemicals Cls was purchased as 100 mg Cls tablets, Otsuka Pharmaceutical Co