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If this insult persists, damaged airway epithelial cells release DAMPs such as HMGB1, mitochondrial DNA, ATP, and S100 proteins, which engage pattern recognition receptors (TLRs, NLRs) on resident and infiltrating immune cells and prolong signalling beyond the initial insult [20, 34]

Interestingly, the formation of TLS was significantly inhibited in the kidneys of sulfasalazine-treated mice (Figure 4, BD)

Mov Disord 2021;36:(suppl 1)

In our paper, we aim to determine serum levels of markers for oxidative stress in pwMS by examining parameters of antioxidant capacity measured in different ways and through various pathways, as well as products derived from oxidative stress in lipids and DNA

Functional links between 5-hydroxymethylcytosine and histone lysine methylation are in focus of current research, for example the ability of Uhrf1 and MeCP2 to als bind to 5hmC