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There are additional important metabolites of nicotine that are not formed to any great extent endogenously as shown by experiments with nicotine patches as the drug delivery method, but are formed during the tobacco smoking process

This process can be affected by nicotine since it speeds up transportation time leading to diarrhea or frequent passing out of watery stools, but on the other hand, some people could experience the opposite effect, where bowel spasms due to the use of nicotine, thereby causing constipation

Nausea, vomiting, and stomach cramps

The amount of time nicotine stays in your system is determined by a variety of factors, including how much you smoke, how regularly you use it, and your overall health

his former wife, Peggy Johnson