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Research suggests that between 7 and 28 days post-surgery, cell aging induced by mechanical stress on endothelial cells is a critical signal for terminating LR (Langiewicz et al., 2017

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Conclusion In healthy, omnivorous adults ( n = 16), a single dose of pomegranate extract (1.6 g) did not reduce plasma TMAO response following an OCC

10.1016/j.lfs.2022.121207 Summary Keywords coronary heart disease, ferroptosis, iron metabolism, mechanism, clinical intervention strategies Citation Liu Y, Yu Z, Lu Y, Liu Y, Chen L and Li J (2025) Progress in the study of the mechanism of ferroptosis in coronary heart disease and clinical intervention strategies

Additional strategies aim to disrupt mitochondrial function through VDAC1 blockade or to reduce tumor hypoxia using hypoxia-activated prodrugs, hyperbaric oxygen therapy, and oxygen-transporting agents