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(3) Stage 1: Genetic Predisposition In the initial stage, a person will have the genetic predisposition for Hashimotos, but they will not have been exposed to the necessary triggers, and thus will have normal TSH and T4/T3 hormones

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Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway

Additionally, topiramate offers the added benefits of weight reduction might via improving insulin resistance in myocytes and adipocytes (Yang et al., 2024), potentially lowering the risk of complications associated with migraines and positively impacting overall patient health

Endophilin B1 and dynamin 2 cooperatively induce the fission of Golgi membranes during autophagy (Takahashi et al., 2016), while the dynamic clustering of dynamin-amphiphysin 1 rings was suggested to regulate fission of large unilamellar vesicles (Takeda et al., 2018)