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Anisamide-targeted PEGylated gold nanoparticles designed to target prostate cancer mediate: Enhanced systemic exposure of siRNA, tumour growth suppression and a synergistic therapeutic response in combination with paclitaxel in mice

This resulting neuroinflammation directly impairs the brainstem's ability to properly regulate heart rate, blood pressure, and vascular tone, directly leading to the severe tachycardia, debilitating dizziness, and painful blood pooling characteristic of POTS