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This myeloid-driven TGF-1-mediated suppression likely influences the regulatory B cell phenotype observed, which limits their capacity to stimulate T cells and form functional TLS (63, 64)

The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default

Ann Oncol 24(11):2844-9, 2013

Subcutaneous levodopa infusion for Parkinsons disease: 1-year data from the open-label BeyoND study

B 15, 35113544