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Animal experiments were approved by the Wako Animal Experiment Committee in RIKEN (approval number: W2021-2-020(1))

However, controlled studies in humans are needed to confirm any pain-relieving benefits

Ibarra C, Vicencio JM, Estrada M et al (2013) Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors