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A hallmark of the ligand interactions it that both bind FcRn in a strictly pH-dependent manner, with binding at mildly acidic pH (pH 6.55.0) and no binding or release at pH 7.4 [23, 28,29,30,31,32,33,34,35,36,37,38,39,40,41,42]

The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository (proteomexchange.org) with the data set identifier PXD036803 ( The mass spectrometry metabolomics data (2 data sets from kidney and plasma, respectively) have been deposited to the Zenodo repository ( All reagents, softwares, mouse lines, and data repository information are available in Supplemental Table 7

Control of progenitor cell number by mitogen supply and demand

Clinical evidence shows identical effectiveness regardless of injection time

The most frequent comorbidity condition in HS is obesity, affecting up 50% to 75% of the HS patients and acting as a systemic inflammatory amplifier