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[54] also found that increased production of primary and intermediate lipid peroxidation products (hydroxyl radicals, MDA) in PTOA rats

10.1002/art.24407 79 GullbrandS

11 Its also important to note that taking B12 in combination with vitamin B6 and folate (rather than alone) is shown to be most effective for regulating homocysteine levels for some patients and preventing the combined risk of stroke, myocardial infarction (heart attack), and damage to heart cells

Role of gut microbiota in antioxidant synthesis Glutathione, a major antioxidant present in all higher organisms, plays a crucial role in neutralizing reactive oxygen species (ROS) by directly quenching hydroxyl free radicals 93,94