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Both semaglutide and tirzepatide can lead to some muscle loss if weight is lost quickly without adequate protein intake or resistance training

Chem Pharm Bull 70:805811 Yu RMK, Ng PKS, Tan T et al (2008) Enhancement of hypoxia-induced gene expression in fish liver by the aryl hydrocarbon receptor (AhR) ligand, benzo [a] pyrene (BaP)

The amount of cells envisioned for use depends on the desired effect, patient state, etc., and can be determined by one skilled in the art

Aslam HM, Sohail A, Shahid A, Khan MAB, Sharif MU, Kausar R, et al

Others have a variation which results in the enzyme working much more quickly (rapid or ultra-rapid metabolisers)