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IS is caused by the occlusion or narrowing of cerebral blood vessels, resulting in neuronal injury and necrosis in the ischemic core and surrounding penumbra due to insufficient nutrient supply and metabolic disturbances (Figure 2A

Anal Biochem 95:351358 O'Neill ME, Mathews KL (2002) Levene tests of homogeneity of variance for general block and treatment designs

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Treatment helps remove them more quickly and prevents the disease from spreading

Patients may develop weight gain, cold intolerance, fatigue, and lower body temperature and may also have diastolic hypertension