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Photosensitizers with Aggregation-Induced Emission: Materials and Biomedical Applications

On October 4, 2016, Alnylam Pharmaceuticals terminated revusiran, its RNAi therapeutic for Transthyretin amyloidosis with cardiomyopathy, following 19 patient fatalities in a phase 3 trial,, 17 in the treatment cohort compared to 2 in the placebo group,, resulting in a $3.6 billion decline in market capitalization and investor doubt regarding the RNAi platform