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The activation of endothelial nitric oxide synthase ( eNOS ) 12 increases vascular permeability 13 ( Figure 1 )

doi:10.3109/08923979709046977 [DOI] [PubMed] [Google Scholar] 143.Padayatty SJ, Levine M

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Additionally, STK38 interacts with MEKK2 to suppress TLR9 signalling [25], and MEKK2 in turn protects STK38 from calpain-dependent degradation [26]

B7 variants which act through CD28 with improved activity (and with decreased activity through CTLA-4) will have improved capacity to induce activation of T cells