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The change in intracellular ROS levels was plotted as mean fluorescence intensity (MFI)

J.KuljaninM.LajoieG

& Bunevicius, R

For instance, FOXO4-D-Retro-Inverso (DRI) induces the selective apoptosis of senescent cells by inhibiting the FOXO4-p53 interaction 34

In order to prevent this phenomenon, catalase (another antioxidant enzyme) which is abundant in the peroxisomes breaks down H2O2 into water and molecular oxygen, consequently curtailing free radical-induced damage (Fig