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The study focused on high doses of B12 administered via injection, far exceeding typical dietary or supplemental intake

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Outcomes Co-primary endpoints were percentage change in body weight from baseline to week 104 and achievement of weight loss of at least 5% of baseline weight at week 104

Low Dose Naltrexone is a pharmacologically active opioid antagonist, conventionally used at higher doses for opioid addiction and alcohol dependence

In vitro and preclinical studies examine its influence on NAD salvage pathways, energy expenditure mechanisms, and adiposity regulation under controlled experimental conditions