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RK The clinical trial data are either phase 1 or 2 at most, so they are not very mature, but they are promising

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Abbreviations CRP: C-reactive protein DCs: Dendritic cells FOXP3: Forkhead box protein P3 GABAA: -aminobutyric acid type A GATA3: GATA binding protein 3 HIF: Hypoxia-inducible factor HPA: Hypothalamic-pituitary-adrenal IFN: Interferon IL: Interleukin KC: Ketamine cystitis MDSCs: Myeloid-derived suppressor cells MHC II: Major histocompatibility complex class II MMPs: Matrix metalloproteinases NF-B: nuclear factor kappa B NK: Natural killer NMDA: N-methyl-D-aspartate PBMCs: Blood mononuclear cells PD-1: Programmed cell death protein 1 PGE2: Prostaglandin E2 PPA: Propofol-paravertebral anesthesia ROS: Reactive oxygen species T-bet: T-box expressed in T cells TGF: Transforming growing factor beta Th: T helper TNF-: Tumor necrosis suppressor alfa Tregs: Regulatory T cells References Wang R, Lan C, Benlagha K, Camara NOS, Miller H, Kubo M, et al

Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1