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The upregulated proteins are enriched in the Gene Ontology (GO) 50 terms of collagen-containing extracellular matrix, perineuronal net, lysosome, glutathione metabolic process, etc

Differences between two groups were analyzed using unpaired Students t-test, while comparisons among multiple groups were performed using one-way analysis of variance (ANOVA) followed by Tukeys post hoc test for pairwise comparisons

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