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Reversed-phase HPLC quantifies purity (the 99% threshold for research grade), and liquid-chromatography mass spectrometry (LC-MS) confirms identity by measuring molecular weight

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The evidence was based on experimental data only briefly described in the patent and included models of: gastric ulcers, heart damage, liver damage, pancreatic injury, kidney damage, experimental diabetes, fever, edema, rhinitis, bone fracture, burns, skin wounds, hypersensitivity reactions, pupil dilation, colon injury, tumour growth, radiation injury, red blood cell development, fertility and lactation, tooth damage, several types of central and peripheral nerve damage, and survival from infection with Trichinosis (i.e., tapeworms) as well as several viruses

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In severe osteoarthritis, the limiting problem is often structural joint degeneration