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If glutathione is depleted by an excessive intake of acetimenophen, NAPQI accumulates and interacts with various macromolecules, leading to hepatocyte injury and potentially death from fulminant liver failure

Yang N, Gong F, Liu B, Hao Y, Chao Y, Lei H, Yang X, Gong Y, Wang X, Liu Z

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Inhibition of system Xc - , for example by erastin, depletes intracellular cysteine and GSH [64] , thereby decreasing GPX4 activity and promoting ferroptosis

These ROS further damage mitochondria, induce OS and ultimately cause insufficient energy supply to oocytes and apoptosis in GCs [81]