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The ZDHHC21T209S/T209S mouse model confirms that the mutation significantly increases neuronal excitotoxicity susceptibility and triggers synaptic dysfunction by enhancing FYN palmitoylation, leading to NMDAR2B overactivation and dysfunction and neuronal loss, ultimately resulting in cognitive deficits (168)

Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 19902019: a systematic analysis for the global burden of disease study 2019