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In clear cell renal cell carcinoma studies, the mTOR inhibitor Everolimus has been shown to significantly enhance ferroptosis induced by Erastin and RSL3, through a synergistic mechanism that promotes lipid peroxidation and ROS accumulation, which holds promise for overcoming resistance to mTOR monotherapy (133)

Hydahl, L

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After transport across the outer membrane, iron recovered from human transferrin or lactoferrin is bound by the periplasmic protein FbpA and directed to the inner membrane transporter FbpBC (Stojiljkovic and Srinivasan, 1997), although TonB-independent iron transport processes were reported in N