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Acknowledgements The authors gratefully acknowledge Lallemand Espaa for kindly supplying the yeast-derived products used in this study

The ubiquitin homologue, Bacteroides fragili s ubiquitin (BfUbb), secreted by some strains of the gut bacterium Bacteroides fragilis , is another example of a gut-derived component that may enter systemic circulation following a breach of the intestinal barrier and contribute to the pathogenesis of SLE (Patrick et al