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Specifically, GPX4, utilizing glutathione as a cofactor, converts lipid peroxides into non-toxic lipid alcohols, thus preventing the accumulation of toxic lipid ROS and maintaining intracellular lipid homeostasis [34]

To further corroborate the protective effect of DAPA on DN kidneys through ferroptosis inhibition via Nrf2/HO-1 upregulation, si-Nrf2 mice were treated with DAPA

HSCs are differentiated into common myeloid progenitors (CMPs), which give rise to the entire myeloid lineage [33]

[17] If standard retinol is too irritating, retinaldehyde is the next step down the retinoid hierarchy before reaching bakuchiol

Trehalose protects keratinocytes against ultraviolet B radiation by activating autophagy via regulating TIMP3 and ATG9A