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Pharmacological modulation of the Trx system using synthetic inhibitors, such as auranofin, platinum-based compounds, and PX-12, as well as selected natural compounds including curcumin analogs and flavonoids, has shown efficacy in preclinical GBM models by inducing oxidative stress and enhancing sensitivity to standard therapies

Adequate Documentation: "Patient reports three weeks of progressive left shoulder pain, worse with overhead activities and sleeping on the left side

In most studies, total SOD1 levels in CSF appear to be not significantly different between ALS and neurological/non-neurological controls [92,93,94,95,96]

Hu Q, Ren H, Li G

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