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For example, L-methionine-treated Wistar rats showed no improvement in cognitive tasks following caffeine administration [9], and aged APPsw mice exhibited no enhancement in working memory compared to APPsw mice that received water [47]

Yang Y, Hua QX, Liu J, Shimizu EH, Choquette MH, Mackin RB, Weiss MA (2010) Solution structure of proinsulin: connecting domain flexibility and prohormone processing