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Such distinctive data are also hard to obtain due to the frequent co-existence of combined risk factors

Our ATSE experiments have some limitations that may make the results difficult to translate to the clinical domain and the human condition

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Cultural Norms: In some communities, tobacco use is deeply embedded in social rituals

It differs from moist snuff or chewing tobacco in that it is made from steam-cured tobacco leaves, rather than fire-cured ones, and its health effects are markedly different, with epidemiological studies showing lower rates of cancer and other tobacco-related health problems than cigarettes, American "chewing tobacco", Indian gutka or African-type tobacco products