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doi: 10.3389/fbioe.2025.1548323 Received 19 December 2024 Accepted 28 April 2025 Published 12 May 2025 Volume 13 - 2025 Edited by Tatjana Ilic-Tomic, University of Belgrade, Serbia Reviewed by Debasis Mitra, Graphic Era University, India Wankui Jiang, Nanjing Tech University, China Updates Copyright 2025 Hu, Yuan, Fei, Imdad, Yang, Huang, Mao and Yang

7 USPSTF Assessment of Magnitude of Net Benefit The USPSTF concludes with high certainty that the net benefit of behavioral interventions and FDA-approved pharmacotherapy for tobacco smoking cessation, alone or combined, in nonpregnant adults who smoke is substantial