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A combination of carotenoids, however, is highly potent as compared to individual compounds [103]

Recently, High-resolution MS (HRMS) has been used to discover new bioactive substances such as nutrients in herbal products and dietary supplements, to identify components of food pollutants, and to investigate the pharmacokinetics, oral bioavailability, and tissue distribution of effective ingredients in Chinese medicinals (15, 16)

Muzurovi E, Kraljevi I, Solak M, Dragni S, Mikhailidis DP (2021) Homocysteine and diabetes: Role in macrovascular and microvascular complications

On the other hand, these modifications may introduce charge heterogeneityas is commonly observed with glycosylation due to loss of sialic acid which may then complicate purification, especially with methods such as ion-exchange chromatography (UNIT 8.2)

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