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On rare occasion, a patient may experience tiny bumps beneath the skin, a rash, headache, or itchy skin

The Journal of musculoskeletal medicine, 26(10), 389396

If it has not, I think harder about dose, about the route of administration (oral versus intramuscular), and about other possible contributors

Any persons experiencing adverse vitamin B12 injection side effect reactions - most notably pain or any visible skin reaction at the injection spot - discontinue use and speak to your doctor

Immediate self-care steps work well for many people: a cool compress for 10 to 15 minutes can ease redness and itching, a single-dose oral antihistamine can quiet the immune response, and 1% hydrocortisone may be used sparingly for short courses with your prescriber's go-ahead