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A change in tail intensity (TI) and tail moment (TM) was analysed using the methods of 29,39,40 , whereby the statistical analysis is performed by animal (as opposed to by gel or by cell) using a summary statistic calculated by equation 2: where x is substituted for the median, 75 th , or 90 th percentile based on recommendations by 29,40

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The World Health Organization describes the tobacco epidemic as "one of the biggest public health threats the world has ever faced." It says smoking, including second-hand, kills more than 8 million people per year