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"it has been linked to a reduction in the thickness of layers in the brain, and to brain lesions, involving areas such as the frontal lobe, which plays a role in voluntary movement and control of thinking, and a decrease in activity in the area of the brain that processes vision," said Silverstein

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[5] By 1976 he might already have been aware of the first stages of early-onset Alzheimer's disease, which was to cause his formerly excellent memory and his powers of concentration to fail dramatically