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101 Interestingly, the deletion of the antioxidant gene transcription factor, nuclear erythroid 2 p45-related factor-2 (Nrf2), in DCs leads to oxidative stress in DCs and an enhanced responsiveness of DCs to airborne particulate matter that was characterized by a Th2-biased antigen-specific immune response

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Furthermore, ecological studies are hypothesis-generating design, so the observed relationship is weak and not causal

Animal experiments and treatments Male Sprague Dawley (SD) rats (8 weeks old, weighed 180200 g) were purchased from SLAC Laboratory Animal Co., Ltd