The pathogenesis associated with -syn aggregation depends on three distinct domains of the protein: the N-terminus (including the P1P2 segments, which play a key role in the oligomer-to-fibril transition and harbor familial PD mutations), the hydrophobic NAC domain, and the acidic C-terminus
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Disclosures: Seema Alam: Nothing to Disclose, Bikrant Biharilal Raghuvanshi: Nothing to Disclose, Tamoghna Biswas: Nothing to Disclose, Vikrant Sood: Nothing to Disclose, Rajeev Khanna: Nothing to Disclose, Snigdha Verma: Nothing to Disclose 2113 IMPROVED OUTCOMES OF ACUTE LIVER FAILURE WITH EXTRACORPOREAL LIVER SUPPORT- A MORE THAN A DECADE OF EXPERIENCE FROM A TERTIARY CENTRE Rakhi Maiwall 1 Meenu Bajpai 2 Harsh Vardhan Tevethia 2 Samba Siva Rao Pasupuleti 3 Fagun Sharma 2 Bindiya Arora 2 Sumegh Talwalkar 2 Mohit kumar Prajapati 2 Prashant Agarwal 2 Rajendra Prasad Mathur 2 Chandani Bhagat 2 Sherin Thomas 2 Shiv Kumar Sarin 2 , 1 Institute of Liver and Biliary Sciences, 2 Institute of Liver & Biliary Sciences, 3 Mizoram University, Pachhunga University College Campus Background: There is a reduction in the deaths of acute liver failure (ALF) patients, with use of extracorporeal liver support systems (ECLS), therapeutic plasma-exchange (TPE) and continuous renal replacement therapy (CRRT)
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