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Moreover, the gut microbiota exercises precise control over the patterns of mucosal glycosylation

Moreover, the first global genome-wide epigenetic analysis in VAT 211 from IR and insulin-sensitive (IS) morbidly obese patients identified a novel IR-related gene, the zinc finger protein 714 (ZNF714) exhibited the highest DNA methylation difference, and its methylation levels is lower in IR patient than in IS patient, consistent with increased transcription levels, such studies provide potential epigenetic biomarkers related to IR in addition to novel treatment targets for the prevention and treatment of metabolic disorders

Most coherent gut-specific positioning: Barrier BPC-GI Barrier makes the clearest case that its objective is exposure along the gut lining rather than simply maximizing systemic absorption

pmid:25593012 58

doi: 10.1371/journal.pntd.0004806 [DOI] [PMC free article] [PubMed] [Google Scholar] 167