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B12 is powerful, but it cannot compensate for unmanaged thyroid issues, chronic infections, overtraining, or sleep deprivation

Mood Enhancement: Some studies suggest that B-12 injections may play a role in mood regulation and emotional well-being, potentially alleviating symptoms of depression and anxiety

Oral is a reasonable option for patients who cannot or will not inject, but want systemic rather than purely local effect

Because it modulates a methylation and NAD+ pathway, interactions with other metabolically active compounds cannot be ruled out and have not been characterised in humans