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In addition to the PFOS-induced pERK1/2 that is involved in autophagy activation, we revealed the inhibition of pmTOR and pAKT in PFOS-mediated RTC autophagy, which is an effect that can be reversed through l-Carnitine pretreatment (Fig

The results of our study show that topiramate was superior to propranolol for the management of CVS

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Carnitine is most abundantly found in foods of animal origin

We propose a cellular model of CVS in which an aberrant ion gradient begets mitochondrial dysfunction which begets further anomalous ion gradients, etc., forming a pathogenic vicious cycle leading to cellular hyperexcitability (Figure 1)