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Comp Biochem Physiol Part B: Biochem Mol Biol (2004) 139:73744

In animal models of hypertension, supplementation of BH 4 improved blood pressure and endothelial dysfunction

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At pH 3.88 (acetate form), accelerated stability testing shows degradation to 21.3% remaining after extended heat stress, while at pH 8.42 (sodium salt), 96.7% remains under identical conditions