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However, during inflammatory condition where there is a high demand to consume NADPH, G6PD is released from its inhibition and forms an active homodimer (51, 52)

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Figure 9 MSH functions as a cofactor for many redox enzymes that are involved in the detoxification of peroxides, electrophiles (formaldehyde), NO, aromatic compounds (maleylpyruvate) and arsenate (Fahey, 2013) (Table 1)