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PMID 31871558

Because carbon dioxide is released from the lungs, blood that leaves the lungs and reaches body tissues has a lower partial pressure of carbon dioxide than is found in the tissues

Then the number of lung cancer deaths in the population over and above the expected baseline is assumed to reflect the amount of smoking in that populationand in particular, the amount of damage caused by smoking, which is a function of the number of smokers and how much each has smoked over his or her lifetime

That is what is called a meteoric rise