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Campisi, Senescence-Associated secretory phenotypes reveal cell-nonautonomous functions of Oncogenic RAS and the p53 tumor suppressor

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Pastore A, Noce A, Di Giovamberardino G, De Stefano A, Calla C, Zenobi R,

The FDA keeps citing firms that fail to demonstrate: Insufficient evidence of process control Validation executed with incomplete protocols Cleaning validation skipped or outdated CAPAs closed without demonstrating actual effectiveness This is where scientific justification and documentation need to work hand in hand