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doi: 10.3389/fchem.2025.1643663 Received 09 June 2025 Accepted 15 August 2025 Published 05 September 2025 Volume 13 - 2025 Edited by Ahmed A

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Excessive iron levels can generate produce ROS via the Fenton reaction, activating various intracellular signaling pathways that enhance bone absorption and inhibit bone formation, thereby contributing to osteoporosis