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Co-enzyme B12 also interacts with the enzyme methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase), required for the conversion of homocysteine to methionine, which is essential for folic acid metabolism and the formation of thymine, which is a component of DNA

SNRIs: Drugs such as venlafaxine (Effexor) or duloxetine (Cymbalta) offer another class of antidepressants that might be effective

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Gradual dose escalation allows healthcare providers to monitor how each patient responds before making adjustments

Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species